cold-type field-emission scanning electron microscope (cold-fe sem  (Hitachi Ltd)

Journal: Pharmaceutics

Article Title: Systemic Design and Evaluation of Ticagrelor-Loaded Nanostructured Lipid Carriers for Enhancing Bioavailability and Antiplatelet Activity

doi: 10.3390/pharmaceutics11050222

Figure Lengend Snippet: ( A ) Particle size distribution of TGL-NLC measured with electrophoretic light scattering (ELS) analyzer. The SEM image of ( B ) raw TGL and ( C ) TGL-NLC. ( D ) DSC thermograms of raw TGL, glycerol monostearate, Capmul MCM, poloxamer 188, Tween 80, blank-NLC, TGL-NLC, and physical mixture. ( E ) PXRD patterns of raw TGL, glycerol monostearate, poloxamer 188, blank-NLC, TGL-NLC, and physical mixture. ( F ) In vitro TGL release profiles of raw TGL and TGL-NLC in pH 1.2 medium with 1 w / v % Tween 80. Data are expressed as the mean ± SD (n = 3). Abbreviation: SEM, scanning electron microscopy; DSC, differential scanning calorimetry; PXRD, powder X-ray diffraction; blank-NLC, nanostructured lipid carriers without ticagrelor.

Article Snippet: Then, TGL-NLC was installed in a cold type field emission (FE)-SEM (S-4800; Hitachi High-Technologies, Tokyo, Japan), and the morphology was observed.

Techniques: In Vitro, Electron Microscopy

Journal: Pharmaceutics

Article Title: Systemic Design and Evaluation of Ticagrelor-Loaded Nanostructured Lipid Carriers for Enhancing Bioavailability and Antiplatelet Activity

doi: 10.3390/pharmaceutics11050222

Figure Lengend Snippet: Ex vivo antiplatelet activities after single oral administration of raw TGL and TGL-NLC at a dose equivalent to 10 mg/kg of TGL. Data are expressed as the mean ± SEM (n = 6). # p < 0.05 vs. raw TGL at the same time-point.

Article Snippet: Then, TGL-NLC was installed in a cold type field emission (FE)-SEM (S-4800; Hitachi High-Technologies, Tokyo, Japan), and the morphology was observed.

Techniques: Ex Vivo